Songmin Ying | Immunology | Best Researcher Award

Prof. Dr. Songmin Ying | Immunology | Best Researcher Award

MD, PhD at Zhejiang University, China

Songmin Ying is a Qiushi Distinguished Professor and Doctoral Supervisor at Zhejiang University School of Medicine. He serves as the Executive Dean and Director of the Zhejiang-Denmark Joint Laboratory for Regenerative and Aging Medicine. His research focuses on chronic airway diseases, aging medicine, and pharmacology. Dr. Ying has held various prestigious academic and research positions, including at the University of Oxford and the Technical University of Munich. With an extensive publication record in high-impact journals, he has significantly contributed to immunology, oncology, and respiratory medicine. His pioneering research has garnered numerous accolades, cementing his reputation as a leader in biomedical sciences.

Professional Profiles📖

Google Scholar

Education 🎓

Dr. Ying’s academic journey began at Shantou University School of Medicine, where he earned his Bachelor’s degree in Clinical Medicine (2003-2007). He then pursued a Master’s in Molecular Genetic Medicine at the University of Sheffield (2007-2010), followed by a Doctorate in Biochemistry at the Technical University of Munich (2010-2013). His postdoctoral training took place at the University of Oxford in the Department of Oncology and the Weatherall Institute of Molecular Medicine. This diverse and prestigious academic background has equipped him with expertise in molecular medicine, respiratory diseases, and translational pharmacology.

Work Experience💼

Dr. Ying’s career is marked by leadership roles in medical research and academia. He has been a Research Fellow and Professor at the Institute of Respiratory Diseases, Zhejiang University, since 2013. In 2023, he was appointed Executive Dean of Zhejiang University School of Medicine, where he oversees groundbreaking biomedical research. His role as Director of the Zhejiang-Denmark Joint Laboratory for Regenerative and Aging Medicine reflects his global research collaborations. His extensive international experience includes significant contributions at the University of Oxford and other renowned institutions.

Awards and Honors 🏆

Dr. Ying has received numerous awards for his contributions to medical research, particularly in immunology and respiratory diseases. He has been recognized with the Qiushi Distinguished Professorship, Zhejiang University’s highest honor. His research has also earned prestigious grants and fellowships, reflecting his impact on aging medicine and airway disease research. He has been invited as a keynote speaker at leading medical conferences worldwide, further solidifying his influence in the scientific community.

Skills💡

Dr. Ying possesses expertise in molecular biology, immunology, pharmacology, and respiratory medicine. His skills include high-throughput sequencing, CRISPR gene editing, and advanced imaging techniques. He is also proficient in bioinformatics analysis and translational medicine strategies. As an academic leader, he has extensive experience in mentoring PhD students and leading multidisciplinary research teams. His collaboration with international institutions enhances his ability to drive innovation in medical sciences.

Research Focus 🔬

Dr. Ying’s research centers on chronic airway diseases, aging medicine, and pharmacology. His work explores the molecular mechanisms of immune responses in respiratory disorders, with an emphasis on eosinophilic inflammation and metabolic adaptation in allergic diseases. He investigates aging-related pathologies and regenerative medicine, aiming to develop targeted therapies for age-associated respiratory diseases. His interdisciplinary approach integrates genomics, bioinformatics, and experimental medicine, positioning his work at the forefront of translational research.

Conclusion✅

Professor Songmin Ying is highly deserving of the Best Researcher Award due to his exceptional research output, leadership, and impact on biomedical sciences. His contributions to chronic diseases, immunology, and aging medicine are globally recognized, making him a strong contender. Further clinical applications and public engagement could enhance his influence even more.

Publications Top Notes📚

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

Citations: 674

Year: 2009

Replication stress activates DNA repair synthesis in mitosis

Citations: 571

Year: 2015

Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1

Citations: 394

Year: 2012

MUS81 promotes common fragile site expression

Citations: 281

Year: 2013

Chlamydia Inhibit Host Cell Apoptosis by Degradation of Proapoptotic BH3-only Proteins

Citations: 253

Year: 2004

Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments

Citations: 209

Year: 2018

Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury

Citations: 201

Year: 2016

Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium

Citations: 178

Year: 2016

Genetic alterations in esophageal tissues from squamous dysplasia to carcinoma

Citations: 170

Year: 2017

Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival

Citations: 158

Year: 2006

Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis

Citations: 140

Year: 2015

Pathological roles of neutrophil‐mediated inflammation in asthma and its potential for therapy as a target

Citations: 123

Year: 2017

Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation

Citations: 114

Year: 2020

LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through AT1R via sponging let-7b in monocrotaline-induced pulmonary arterial hypertension

Citations: 106

Year: 2018

MTOR suppresses cigarette smoke–induced epithelial cell death and airway inflammation in chronic obstructive pulmonary disease

Citations: 102

Year: 2018

DNA-PKcs and PARP1 bind to unresected stalled DNA replication forks where they recruit XRCC1 to mediate repair

Citations: 96

Year: 2016

Broad Degradation of Proapoptotic Proteins with the Conserved Bcl-2 Homology Domain 3 during Infection with Chlamydia trachomatis

Citations: 94

Year: 2005

ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation

Citations: 88

Year: 2021

Effectiveness and safety of PD-1/PD-L1 inhibitors in the treatment of solid tumors: a systematic review and meta-analysis

Citations: 85

Year: 2017

Autophagy plays an essential role in cigarette smoke-induced expression of MUC5AC in airway epithelium

Citations: 82

Year: 2016

Zhong-Yi Dong | Oncology | Best Researcher Award

Pr. Zhong-Yi Dong | Oncology | Best Researcher Award

Teacher at Universidade Federal do Oeste do Pará, China

Dr. Dong Zhongyi, born in August 1985, is an esteemed oncologist specializing in tumor radiotherapy. With over a decade of experience, he serves as Associate Chief Physician in the Department of Radiotherapy at Southern Hospital, Southern Medical University. He leads the lung cancer subspecialty group and mentors postgraduate students. Dr. Dong has received numerous accolades, including recognition in the “World’s Top 2% Scientists” (2024) and the “Guangdong Special Support Plan for Young Top Talents in Health.” His research contributions include over 20 high-impact publications and multiple national patents. He has been invited to present at international and domestic conferences and has secured major research grants. Dr. Dong actively participates in academic leadership, holding key positions in multiple professional medical committees in Guangdong, China. His work significantly advances the field of oncology, particularly in radiotherapy and immunotherapy for lung cancer.

Professional Profiles📖

ORwID

Education 🎓

Dr. Dong Zhongyi pursued his medical education at prestigious institutions, building a strong foundation in oncology and clinical medicine. He earned his Bachelor of Clinical Medicine from the University of South China, School of Medicine (2004-2009). This early training equipped him with essential medical knowledge and clinical skills. Following his undergraduate studies, he specialized further by obtaining a Master’s degree in Oncology (2009-2012) from Southern Hospital, Southern Medical University. During this time, he developed expertise in cancer treatment and research, particularly in radiotherapy and targeted therapies. Dr.Dong then advanced his academic journey with a Ph.D. in Oncology (2014-2017) from the Lung Cancer Research Institute, Guangdong Provincial People’s Hospital, under the mentorship of Professor Yilong Wu. His doctoral research focused on the molecular mechanisms of immune resistance and tumor microenvironments, providing critical insights into cancer progression and treatment strategies. This work laid the foundation for his impactful contributions to clinical oncology and translational medicine.

Work Experience💼

Dr. Dong Zhongyi has built a distinguished career in oncology, marked by extensive clinical practice, research, and teaching in tumor radiotherapy. He began his professional journey as a Resident Physician (2012-2014) at Xiangtan Central Hospital, Hunan Province, where he gained hands-on experience in patient care and medical oncology. This period helped him develop a strong clinical foundation in cancer treatment. Following this, he advanced to the role of Attending Physician (2017-2022) at Southern Hospital, Southern Medical University, where he further honed his expertise in lung cancer treatment and radiotherapy. His dedication to integrating research with clinical practice significantly improved patient outcomes. Currently, Dr. Dong serves as an Associate Chief Physician (2022-Present) at Southern Hospital, Southern Medical University, where he continues to lead advancements in oncology. In addition to his clinical role, he is deeply involved in medical education, serving as a Master’s Supervisor (2021-Present) and Doctoral Supervisor (2024-Present). Throughout his career, Dr. Dong has remained at the forefront of lung cancer research, pioneering innovative treatment strategies and leading multiple research projects. His commitment to mentoring young medical professionals has played a crucial role in shaping the next generation of oncologists

Awards and Honors 🏆

Dr. Dong Zhongyi has received numerous prestigious awards in recognition of his exceptional contributions to lung cancer research and oncology. He was honored with the “Guangdong Special Support Plan for Young Top Talents in Health,” reflecting his leadership in medical research. In 2024, he was listed among the “World’s Top 2% Scientists,” a testament to his global impact in oncology. His achievements in lung cancer research were further acknowledged when he ranked 41st among China’s Top 100 Schors in Lung Cancer (2022). Additionally, he received the IASLC Developing Nation Award twice, in 2016 and 2020, highlighting his contributions to international lung cancer research. In 2020, Dr. Dong was awarded the First Prize of the Guangdong Natural Science Award, recognizing his groundbreaking work in tumor radiotherapy and cancer treatment. His dedication to advancing oncology has also been supported by prestigious talent programs, including the “National Outstanding Young Scientist Cultivation Plan (Class A)” and the “Excllent Young Scientist Cultivation Plan” by Southern Medical University. These accolades underscore Dr. Dong’s remarkable impact on the field, cementing his status as a leading researcher and clinician in lung cancer treatment and translational medicine.

Skills💡

Dr. Dong Zhongyi is a distinguished expert in oncology research and clinical application, seamlessly integrating cutting-edge research into patient care. His expertise in radiotherapy and immunotherapy has contributed to advanced cancer treatment strategies, improving therapeutic outcomes. With a strong foundation in molecular and translational medicine, he continuously innovates in tumor biology, enhancing precision oncology approaches. As a prolific researcher, Dr. Dong has authored over 20 high-impact scientific papers, demonstrating his excellence in scientific writing and publishing. His commitment to academic mentorship is evident in his role as a supervisor for postgraduate research, nurturing the next generation of oncology professionals. Additionally, his contributions to medical innovation and patents—holding multiple invention patents—underscore his role as a leader in oncology research and education. Through these skills, Dr. Dong continues to drive advancements in cancer treatment and medical science.

Research Focus 🔬

Dr. Dong Zhongyi’s research encompasses both clinical and translational oncology, with a strong focus on advancing lung cancer treatment. His work in radiotherapy and immunotherapy has led to significant advancements in treatment strategies, improving patient survival and quality of life. He has extensively investigated the molecular mechanisms of immune resistance, shedding light on how tumor microenvironments influence therapy effectiveness. Additionally, Dr. Dong has contributed to understanding and mitigating the adverse effects of immunotherapy, developing strategies to enhance patient safety and treatment efficacy. His groundbreaking research has influenced global oncology guidelines and has been cited in expert consensus documents, underscoring his role in shaping the future of cancer care. By refining precision medicine approaches, his work continues to drive innovation in oncology, ultimately improving patient outcomes worldwide.

Conclusion✅

Dr. Dong Zhongyi is a highly deserving candidate for the Best Researcher Award. His groundbreaking contributions to lung cancer research, impressive publication record, and leadership in the oncology community make him a standout researcher. While expanding international collaborations and clinical impact could further enhance his profile, his achievements thus far position him as a strong contender for this prestigious recognition.

Publications Top Notes📚

 

CDK4/6 inhibition triggers ICAM1-driven immune response and sensitizes LKB1 mutant lung cancer to immunotherapy

Journal: Nature Communications

Year: 2023

PMID: 36871040

Citations: [Check Citation Data]

PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer

Journal: Cancer Research

Year: 2023

PMID: 36512628

Citations: [Check Citation Data]

Interstitial pneumonitis associated with combined regimen of immunotherapy and conventional therapies-pharmacovigilance database analysis with real-world data validation

Journal: BMC Medicine

Year: 2023

PMID: 36600276

Citations: [Check Citation Data]

Splenomegaly in predicting the survival of patients with advanced primary liver cancer treated with immune checkpoint inhibitors

Journal: Cancer Medicine

Year: 2022

DOI: 10.1002/cam4.4818

Citations: [Check Citation Data]

Organ-specific metastatic landscape dissects PD-(L)1 blockade efficacy in advanced non-small cell lung cancer

Journal: BMC Medicine

Year: 2022

PMID: 35410334

Citations: [Check Citation Data]

Inferring Homologous Recombination Deficiency of Ovarian Cancer From the Landscape of Copy Number Variation

Journal: Frontiers in Oncology

Year: 2021

DOI: 10.3389/fonc.2021.772604

Citations: [Check Citation Data]

Assessment of anti-PD-(L)1 for patients with coexisting malignant tumor and tuberculosis classified by active, latent, and obsolete stage

Journal: BMC Medicine

Year: 2021

DOI: 10.1186/s12916-021-02194-z

Citations: [Check Citation Data]

De Novo Mutation in Non-Tyrosine Kinase Domain of ROS1 as a Potential Predictor of Immune Checkpoint Inhibitors in Melanoma

Journal: Frontiers in Oncology

Year: 2021

PMID: 34221982

Citations: [Check Citation Data]

Efficacy and Treatment Strategies in Advanced Cancers with Liver Metastasis Receiving Atezolizumab Therapy

Journal: Cancer Management and Research

Year: 2021

PMID: 34135631

Citations: [Check Citation Data]

Integrative evaluation of primary and metastatic lesion spectrum to guide anti-PD-L1 therapy of non-small cell lung cancer

Journal: Oncoimmunology

Year: 2021

PMID: 33996262

Citations: [Check Citation Data]

Development and validation of a genomic mutation signature to predict response to PD-1 inhibitors in non-squamous NSCLC

Journal: Journal for ImmunoTherapy of Cancer

Year: 2020

DOI: 10.1136/jitc-2019-000381

Citations: [Check Citation Data]

Development and interpretation of a pathomics-based model for the prediction of microsatellite instability in Colorectal Cancer

Journal: Theranostics

Year: 2020

DOI: 10.7150/thno.49864

Citations: [Check Citation Data]

HPV-positive status associated with inflamed immune microenvironment and improved response to anti-PD-1 therapy in head and neck squamous cell carcinoma

Journal: Scientific Reports

Year: 2019

DOI: 10.1038/s41598-019-49771-0

Citations: [Check Citation Data]

Combination of TMB and CNA stratifies prognostic and predictive responses to immunotherapy across metastatic cancer

Journal: Clinical Cancer Research

Year: 2019

DOI: 10.1158/1078-0432.ccr-19-0558

Citations: [Check Citation Data]

Strong Programmed Death Ligand 1 Expression Predicts Poor Response and De Novo Resistance to EGFR Tyrosine Kinase Inhibitors Among NSCLC Patients With EGFR Mutation

Journal: Journal of Thoracic Oncology

Year: 2018

PMID: 30056164

Citations: [Check Citation Data]

VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Journal: BMC Cancer

Year: 2018

PMID: 29720116

Citations: [Check Citation Data]

Genetic and Immune Profiles of Solid Predominant Lung Adenocarcinoma Reveal Potential Immunotherapeutic Strategies

Journal: Journal of Thoracic Oncology

Year: 2017

PMID: 29127022

Citations: [Check Citation Data]

EGFR mutation correlates with uninflamed phenotype and weak immunogenicity, causing impaired response to PD-1 blockade in non-small cell lung cancer

Journal: Oncoimmunology

Year: 2017

PMID: 29147605

Citations: [Check Citation Data]

Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma

Journal: Clinical Cancer Research

Year: 2017

PMID: 28039262

Citations: [Check Citation Data]

Mixed Responses to Systemic Therapy Revealed Potential Genetic Heterogeneity and Poor Survival in Patients with Non-Small Cell Lung Cancer

Journal: The Oncologist

Year: 2017

PMID: 28126915

Citations: [Check Citation Data]

Potential biomarker for checkpoint blockade immunotherapy and treatment strategy

Journal: Tumour Biology

Year: 2016

PMID: 26779629

Citations: [Check Citation Data]

FAT10 promotes hepatitis B virus-related hepatocellular carcinoma progression via Akt/GSK3β pathway

Journal: Oncogene

Year: 2013

PMID: 23812429

Citations: [Check Citation Data]

 

You Zhai | Immunotherapy | Best Researcher Award

Dr. You Zhai | Immunotherapy | Best Researcher Award

Residency at Beijing Tiantan Hospital, Capital Medica, China

You Zhai is a prominent researcher in immunotherapy, specializing in CAR-T cell therapy for glioma and leukemia. Currently pursuing his doctoral studies at the Beijing Neurosurgical Institute, Capital Medical University, under the mentorship of Professor Tao Jiang, he has made significant strides in targeted immunotherapies. His research focuses on the development of CAR-T cell therapies for glioblastoma and other cancers. With extensive experience in molecular neuropathology and genetic engineering, he has contributed to various groundbreaking studies, with notable work on the trogocytosis of CAR molecules and tumor antigen escape. Zhai has published extensively in top-tier journals and holds several national patents related to his research. He is dedicated to improving patient outcomes through innovative therapies, aiming to advance the field of cancer immunotherapy.

Professional Profiles📖

Scopus

Education 🎓

You Zhai began his educational journey at The High School Affiliated to Renmin University of China, completing his studies in 2013. He then pursued a degree in Clinical Medicine at Shanghai Jiao Tong University School of Medicine, graduating in 2018. During his undergraduate years, Zhai was actively involved in research, working under Professor Han L at the Shanghai Institute of Hematology, contributing to the development of CAR-T therapies for leukemia. This experience laid the foundation for his future research focus. Zhai’s academic pursuits continued at the Beijing Neurosurgical Institute, Capital Medical University, where he joined the research team of Professor Tao Jiang to explore CAR-T therapies for glioma. His education has been marked by a strong blend of clinical knowledge and innovative scientific inquiry, leading to groundbreaking discoveries in cancer immunotherapy.

Work Experience💼

You Zhai’s research experience spans several years, with notable contributions to CAR-T cell therapies for both leukemia and glioblastoma. From 2014 to 2016, Zhai worked at the State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, focusing on TanCAR T cells targeting CD19 and CD133 to combat MLL leukemic cells. His undergraduate work led to co-first authorship in the journal Leukemia. In 2018, Zhai joined the Beijing Neurosurgical Institute’s Department of Molecular Neuropathology, where he focused on developing dual-targeted IL7Rα-CAR-T cells against glioblastoma. His involvement in the clinical trial of Tris-CAR-T cells for recurrent glioblastoma (NCT05577091) exemplifies his hands-on approach to research, from lab work to clinical trials. Zhai has actively contributed to multiple national patents, advancing targeted drug and cell therapy research. He is now a key technical member in the “Beijing Engineering Research Center for Targeted Drugs and Cell Therapy of Nervous System Tumors.”

Awards and Honors 🏆

You Zhai’s academic excellence and significant contributions to cancer immunotherapy have earned him several prestigious awards and honors. In 2024, he received the IFIA Best Invention Award at iENA2024 for his innovations in immunotherapy. His research was selected for an oral presentation at EANO2024, a major neuro-oncology conference. Zhai’s work has been recognized by the Wang Zhongcheng Scholarship, awarded in June 2024 for his outstanding academic achievements. He has also gained international recognition, having participated in training programs at esteemed institutions like UBC-BC Children’s Hospital (2016) and UCLA (2014). Additionally, he is a member of the Society for Neuro-Oncology of China, further underscoring his leadership in the field. These awards reflect his ongoing dedication to advancing cancer therapies and the field of immunotherapy.

Skills 💡

You Zhai possesses a diverse set of skills crucial to his research in immunotherapy and cancer treatments. He is proficient in scientific research software such as GraphPad, SPSS, and various molecular biology techniques including Western blotting, flow cytometry, immunohistochemistry, and immunofluorescence. Zhai is also highly skilled in advanced experimental techniques like immunoprecipitation, tissue and organoid slicing, and establishing mouse intracranial xerograph tumor models. Additionally, he is well-versed in scientific achievement translation, clinical trial progress, and protocol preparation, making him an asset to any project from laboratory development to clinical application. His expertise extends to the use of Microsoft Office for presentation creation, as well as Photoshop and other design software for scientific communication. These technical skills, combined with his deep knowledge of molecular neuropathology and cancer immunotherapy, enable Zhai to make significant strides in advancing cancer therapies and improving patient outcomes.

Research Focus 🔬

You Zhai’s primary research focus is the development of CAR-T cell therapies for gliomas and other cancers, particularly glioblastoma, through targeted immunotherapies. His work seeks to address challenges such as tumor resistance to CAR-T cells, antigen escape, and the optimization of immunotherapeutic strategies. Zhai has developed dual-targeted IL7Rα-CAR-T cells aimed at enhancing the antitumor efficacy against glioblastoma by targeting the CD44 and CD133 antigens. His pioneering work on “cellular nibbling” proposes a new theoretical framework to understand short-term tumor immune escape. Zhai’s ongoing clinical trials and collaborations with pharmaceutical companies aim to translate his research findings into effective therapies. Additionally, his research has expanded to include immune checkpoint-based CAR-T cells for brain gliomas. He envisions a future where immunotherapy significantly improves the prognosis of cancer patients, focusing on personalized, more effective treatments for solid tumors like glioblastoma.

Conclusion✅

You Zhai is an outstanding candidate for the Best Researcher Award due to his innovative contributions to cancer immunotherapy, particularly in the development of CAR-T cell therapies for glioblastoma and leukemia. His research not only advances scientific knowledge but has the potential to revolutionize cancer treatment, particularly in the field of immunotherapy. While there are areas for improvement in terms of broader dissemination and long-term outcome studies, his impressive academic achievements, patents, and recognition in the scientific community position him as a highly deserving recipient of the award. His dedication to improving patient prognosis and his pioneering work in immunotherapy make him an exemplary researcher in his field.

Publications Top Notes📚

You Zhai, Guanzhang Li, Changqing Pan, Wei Zhang, Tao Jiang
Title: The development and potent antitumor efficacy of CD44/CD133 dual-targeting IL7Rα-armored CAR-T cells against glioblastoma
Year: 2025
Source: Cancer Letters
Citations: 0 (as of the latest information)
Full Text Status: Open Access

Lele Wu, Zheng Zhao, Yong-jae Shin, Tao Jiang, Vinay B. Tergaonkar
Title: Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma
Year: 2024
Source: Nature Cell Biology, Volume 26, Issue 6, Pages 1003-1018
Citations: 0 (as of the latest information)