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Dr. Mengtian Ren | Nucleic Acids | Best Researcher Award

Lecturer at Tiangong University, China 

Dr. Mengtian REN is an Assistant Professor at the School of Chemistry, Tiangong University, Tianjin, China, where he has been employed since July 2023. His research primarily focuses on the mechanistic understanding of DNA oxidative damage andWrepair, DNA–protein crosslink formation, and the cGAS-STING immune signaling pathway. Dr. REN has a strong academic foundation, earning his Bachelor of Science in Applied Chemistry from Northeastern University, followed by a Ph.D. in Organic Chemistry from Nankai University, Tianjin. He also pursued a joint Ph.D. in Biochemistry and Molecular Biology at the Gene Center in Munich, Germany. Dr. REN has made significant contributions to understanding DNA damage repair processes, especially in relation to histones and nucleosomes. His work has been published in prestigious journals, and he has actively contributed to various research funding projects.

Professional Profiles📖

ORCID

Education 🎓

Dr. Mengtian REN earned his Bachelor of Science degree in Applied Chemistry from Northeastern University in Shenyang, China, in 2017. During his undergraduate studies, he gained strong theoretical and practical knowledge in chemistry, setting the foundation for his future research. He continued his academic journey with a Ph.D. in Organic Chemistry from Nankai University in Tianjin, China, completed in 2023. His doctoral research focused on understanding DNA oxidative damage and repair, a key area in biochemistry and molecular biology. In addition to his doctoral studies, Dr. REN pursued a joint Ph.D. in Biochemistry and Molecular Biology at the Gene Center in Munich, Germany, from May to December 2022. This international experience enriched his research perspective and broadened his scientific skills. Dr. REN’s diverse educational background reflects his commitment to advancing in the fields of chemistry, biochemistry, and molecular biology.

Work Experience💼

Dr. Mengtian REN began his career as an Assistant Professor at the School of Chemistry, Tiangong University, in Tianjin, China, in July 2023. Prior to this, he completed his Ph.D. studies at Nankai University, focusing on organic chemistry and DNA damage repair mechanisms. He also participated in a joint Ph.D. program at the University of Munich’s Gene Center, where he expanded his research in biochemistry and molecular biology. Dr. REN’s research delves into DNA oxidative damage and repair, the biological consequences of DNA-protein crosslinks, and the cGAS-STING immune pathway. He has been awarded several grants, including the National Natural Science Foundation of China Youth Science Fund Project, which supports his independent research. In addition to his research, Dr. REN teaches courses in molecular biology and molecular biology experiments, guiding the next generation of scientists. His broad academic and research experiences make him a key contributor to his field.

Awards and Honors 🏆

Dr. Mengtian REN has been recognized for his outstanding contributions to the field of organic chemistry and molecular biology. He has received various grants to support his research, including the prestigious National Natural Science Foundation of China’s Youth Science Fund Project (Grant No. 22407100), where he serves as the Principal Investigator. His work is highly regarded in the scientific community, earning him several opportunities to collaborate with international researchers. Dr. REN has also contributed to the Tianjin Undergraduate Innovation and Entrepreneurship Training Program, mentoring students who have gone on to make their own contributions to science. These honors reflect his expertise and the high regard in which he is held within the academic community. His research publications in leading journals such as Nature Communications and Nucleic Acids Research further cement his reputation as a rising star in molecular biology and biochemistry.

Skills 💡

Dr. Mengtian REN possesses a wide range of technical skills, honed through his years of research and teaching experience. He is highly skilled in molecular biology techniques, particularly in DNA damage repair studies. His expertise includes the use of advanced biochemical and biophysical methods to study DNA-protein interactions, DNA oxidative damage, and repair mechanisms. Dr. REN is proficient in molecular cloning, protein expression and purification, cell culture, and the analysis of gene expression. His work in cGAS-STING signaling pathway research also requires proficiency in immunological assays, protein-protein interaction analysis, and various cell-based assays. Moreover, Dr. REN is adept at data analysis and computational modeling to understand DNA repair processes within nucleosome core particles. His research also involves working with cutting-edge technologies, including photo-crosslinkers and high-throughput screening techniques. His multidisciplinary expertise enables him to tackle complex biochemical questions, contributing significantly to the understanding of DNA damage and repair.

Research Focus 🔬

Dr. Mengtian REN’s research primarily revolves around DNA oxidative damage and repair mechanisms, with a particular focus on DNA–protein crosslinks and their biological consequences. His research explores the complex interactions between DNA and proteins within nucleosomes, an area that has significant implications for understanding cellular responses to DNA damage. Dr. REN also investigates the cGAS-STING immune signaling pathway, which plays a crucial role in innate immunity and cancer therapy. His work is at the intersection of chemistry, biochemistry, and molecular biology, seeking to unravel the mechanisms of DNA damage and its repair, while also identifying potential therapeutic targets. Dr. REN’s pioneering research is crucial for understanding how cells respond to DNA damage, which can lead to better strategies for combating diseases like cancer, neurodegenerative disorders, and other DNA-related conditions. His contributions continue to advance the field of DNA repair and immune response mechanisms.

Conclusion✅

Dr. Mengtian REN’s remarkable scientific contributions to the understanding of DNA damage repair mechanisms and immune signaling make him a fitting candidate for the Best Researcher Award. His research not only enhances the academic community’s understanding of cellular processes but also paves the way for future therapeutic innovations. With his proven record of high-impact publications and leadership in funded projects, he exemplifies the qualities of a groundbreaking researcher.

Publications Top Notes📚

Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles Authors: Mengtian Ren; Fabian Gut; Yilan Fan; Jingke Ma; Xiajing Shan; Aysenur Yikilmazsoy; Mariia Likhodeeva; Karl-Peter Hopfner; Chuanzheng Zhou


Journal: Nature Communications
Publication Date: October 31, 2024
DOI: 10.1038/s41467-024-53811-3
Type: Journal article

Mengtian Ren | Nucleic Acids | Best Researcher Award

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