PhD candidate at Institute of Molecular Biology and Biotechnology of the Foundation for Research and Technology Hellas (IMBB-FORTH), Greece
Syrago Spanou is an accomplished neuroscientist and Ph.D. candidate whose research bridges molecular biology, neurodegeneration, and regenerative medicine. With expertise spanning neural stem cell biology, tumor suppressor protein function, and Alzheimer’s disease pathology, she has demonstrated exceptional skill in integrating molecular, cellular, and translational neuroscience. Her work has advanced understanding of neural stem cell physiology, neuroinflammation, and novel therapeutic approaches for neurodegenerative disorders, marking her as a promising leader in biomedical research.
Professional Profile
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Education
Syrago’s academic trajectory reflects a strong interdisciplinary foundation in biology, biotechnology, and neuroscience. She earned a Diploma in Biology from the University of Crete, where she explored how the topography of micro-patterned silicon substrates influences neural cell differentiation. She later completed dual Master’s degrees: one in Protein Biotechnology from the University of Crete, focusing on the rescue of autoimmune phenotypes through soluble MHC-II molecules, and another in Neurosciences from the Université de Bordeaux, where she developed innovative therapeutic strategies to restore function in experimental autoimmune encephalomyelitis models. Her educational pathway culminated in her doctoral research at the University of Crete, where her thesis investigates the role of the tumor suppressor PML in neural stem cell physiology and Alzheimer’s disease pathology. Throughout her studies, she also obtained specialized training in scientific procedures involving animals in the UK.
Experience
Her research career spans multiple prestigious laboratories and international collaborations. As a Ph.D. student at the Institute of Molecular Biology and Biotechnology (IMBB-FORTH), she has conducted groundbreaking studies on how PML regulates neural stem cell differentiation, proteostasis, stress tolerance, and mitochondrial function. She also explored PML’s role in modulating microglial activity during neuroinflammation. Her collaborative work with The Francis Crick Institute further expanded her expertise in neuroimmunology and advanced imaging approaches. Prior experiences include projects at University College London on therapeutic interventions in neuroinflammation, studies on autoimmune disorders at the University of Athens, and investigations into microglial regulation and cell fate decisions in neurodegeneration. Her early research in tissue engineering and nanobiotechnology demonstrated her ability to apply multidisciplinary approaches to neuroscience.
Research Focus
Syrago’s research centers on elucidating molecular pathways that govern neural stem cell behavior and their implications for neurodegenerative diseases. By focusing on PML, a multifunctional tumor suppressor protein, she has uncovered mechanisms linking stem cell pluripotency, mitochondrial health, and stress resilience. Her work also explores the interplay between neuroinflammation, microglial activation, and neuronal survival, aiming to develop targeted therapeutic strategies. This integrative perspective bridges fundamental molecular insights with potential translational applications in Alzheimer’s and other neurodegenerative conditions.
Publication Top Notes
Title: Promyelocytic Leukemia Protein (PML) Regulates Stem Cell Pluripotency Through Novel Sumoylation Targets
Authors: Syrago Spanou; Takis Makatounakis; Chrysa Filippopoulou; Georgios Dougalis; George Stamatakis; Christoforos Nikolaou; Martina Samiotaki; Georgia Chachami; Joseph Papamatheakis; Androniki Kretsovali
Journal: Preprint, DOI: 10.20944/preprints202411.1618.v1
Summary: This study uncovers how PML influences stem cell pluripotency via novel sumoylation targets, revealing regulatory mechanisms that control cell fate decisions.
Title: Promyelocytic leukemia protein regulates angiogenesis and epithelial–mesenchymal transition to limit metastasis in MDA‐MB‐231 breast cancer cells
Authors: Amalia P. Vogiatzoglou; Syrago Spanou; Nikoleta Sachini; Elias Drakos; Christoforos Nikolaou; Takis Makatounakis; Androniki Kretsovali; Joseph Papamatheakis
Journal: Molecular Oncology, DOI: 10.1002/1878-0261.13501
Summary: This research demonstrates that PML suppresses breast cancer metastasis by regulating angiogenesis and epithelial–mesenchymal transition pathways.
Title: Cells on hierarchically-structured platforms hosting functionalized nanoparticles
Authors: Chara Simitzi; Pascal Harimech; Syrago Spanou; Christina Lanara; Amelie Heuer-Jungemann; Aleka Manousaki; Costas Fotakis; Anthi Ranella; Antonios G. Kanaras; Emmanuel Stratakis
Journal: Biomaterials Science, DOI: 10.1039/c7bm00904f
Summary: The study explores how surface architecture and nanoparticle functionalization influence cellular adhesion, orientation, and differentiation.
Conclusion
Syrago Spanou’s career exemplifies the qualities of an emerging leader in neuroscience and molecular biology. Her rigorous academic training, innovative research on neural stem cell biology, and commitment to addressing complex neurodegenerative diseases demonstrate her potential to make transformative contributions to biomedical science. Through her publications, international collaborations, and active participation in professional networks, she has established herself as a skilled and impactful researcher. Her achievements position her as a highly deserving candidate for recognition in the field, with a promising trajectory toward shaping the future of neuroscience and regenerative medicine.